Three new compounds from the seeds of Sinapis alba L

Degang Kong; Chuanhou Li; Liang Ding; Zhenhua Tian; Lu Wang; Xue Liu; Qinghe Kong; Honglei Zhou; Lin Liao

doi:10.1080/14786419.2023.2297402

Three new compounds from the seeds of Sinapis alba L

Nat Prod Res. 2023 Dec 24:1-7. doi: 10.1080/14786419.2023.2297402. Online ahead of print.

Authors

Degang Kong¹, Chuanhou Li², Liang Ding³, Zhenhua Tian⁴, Lu Wang¹, Xue Liu¹, Qinghe Kong¹, Honglei Zhou^{1

3}, Lin Liao^{5

6}

Affiliations

¹ College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
² Shandong Medical College, Linyi, China.
³ Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China.
⁴ Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
⁵ First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Department of Endocrinology and Metabology, Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Institute of Nephrology, Jinan, China.
⁶ Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Institute of Nephrology, Jinan, China Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational medicine, Shandong Institute of Nephrology, Jinan, China.

PMID: 38143317
DOI: 10.1080/14786419.2023.2297402

Abstract

Three undescribed compounds, 1-(4-hydroxyphenyl)-3-((4-hydroxyphenyl)thio) -2-propanone (I), 4'-hydroxybenzyl 4-(4''- hydroxybenzyloxy) benzyl thioether (II) and 3-(4'-hydroxybenzyl)-6-hydroxy-quinazolinone (III) were isolated from the seeds of Sinapis alba L. The structures of all compounds were elucidated based on NMR and MS analysis, along with the comparison with published data. The potential targets of compounds I-III were identified by virtual screening. The potential inhibitory effects of these compounds on protein kinase C theta type were compared by molecular docking. The docking score of compound III was the highest.

Keywords: Sinapis Alba L; molecular docking; protein kinase C theta type.