Temporary HMCES-DNA cross-link prevents permanent DNA damage

Penelope D Ruiz; Agata Smogorzewska

doi:10.1016/j.celrep.2023.113594

Temporary HMCES-DNA cross-link prevents permanent DNA damage

Cell Rep. 2024 Jan 23;43(1):113594. doi: 10.1016/j.celrep.2023.113594. Epub 2023 Dec 22.

Authors

Penelope D Ruiz¹, Agata Smogorzewska²

Affiliations

¹ Laboratory of Genome Maintenance, The Rockefeller University, New York, NY, USA.
² Laboratory of Genome Maintenance, The Rockefeller University, New York, NY, USA. Electronic address: asmogorzewska@rockefeller.edu.

Abstract

HMCES, a recently discovered but ancient protein, covalently attaches to damaged single-stranded DNA and shields it from nucleases. Rua-Fernandez and colleagues now show that HMCES catalyzes its own recycling, permitting normal growth and non-mutagenic DNA repair.¹.

Publication types

Comment

MeSH terms

DNA Damage*
DNA Repair
DNA* / metabolism
DNA, Single-Stranded
DNA-Binding Proteins / metabolism

Substances

DNA
DNA, Single-Stranded
DNA-Binding Proteins

Grants and funding

R01 GM140400/GM/NIGMS NIH HHS/United States