Low-Valent-Tungsten-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling Reaction

Chunsheng Li; Yaoyang Chen; Feihua Ye; Junhua Chen; Jia Zheng

doi:10.3390/molecules28248071

Low-Valent-Tungsten-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling Reaction

Molecules. 2023 Dec 13;28(24):8071. doi: 10.3390/molecules28248071.

Authors

Chunsheng Li¹, Yaoyang Chen¹, Feihua Ye¹, Junhua Chen¹, Jia Zheng²

Affiliations

¹ School of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, China.
² The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China.

Abstract

A straightforward and convenient protocol was established for the synthesis of thiophosphates and 3-sulfenylated indoles via low-valent-tungsten-catalyzed aerobic oxidative cross-dehydrogenative coupling reactions. These reactions occur under mild conditions and simple operations with commercially available starting materials, processing the advantage of excellent atom and step economy, broad substrate scope, and good functional groups tolerance. Moreover, this transformation could be practiced on the gram scale, which exhibits great potential in the preparation of drug-derived or bioactive molecules.

Keywords: 3-sulfenylated indoles; aerobic; cross-dehydrogenative coupling; thiophosphates.

Grants and funding

This research was funded by the Guangdong Basic and Applied Basic Research Foundation (2020A1515111156, 2023A1515012657), Zhaoqing University Science Fund (QN202229), College Students’ innovation and entrepreneurship training program (NO. 202310580015), Scientific Research Project of General Universities in Guangdong Province (2022KTSCX046), Zhanjiang Ocean Young Talent Innovation Project (2022E05008).