A game of networks: Do different lipids interact to orchestrate inflammatory homeostasis?

Alessandro Leuti; Marina Fava; Mauro Maccarrone

doi:10.1016/j.chembiol.2023.11.001

A game of networks: Do different lipids interact to orchestrate inflammatory homeostasis?

Cell Chem Biol. 2023 Dec 21;30(12):1499-1501. doi: 10.1016/j.chembiol.2023.11.001.

Authors

Alessandro Leuti¹, Marina Fava², Mauro Maccarrone³

Affiliations

¹ Department of Medicine, Campus Bio-Medico University of Rome, 00128 Rome, Italy; European Center for Brain Research/Institute for Research and Health Care (IRCCS) Santa Lucia Foundation, 00143 Rome, Italy.
² Department of Medicine, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
³ European Center for Brain Research/Institute for Research and Health Care (IRCCS) Santa Lucia Foundation, 00143 Rome, Italy; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy. Electronic address: mauro.maccarrone@univaq.it.

PMID: 38134878
DOI: 10.1016/j.chembiol.2023.11.001

Abstract

Resolution of inflammation is the physiological process whereby endogenous pro-resolving lipids constrain inflammatory stimuli that would otherwise cause chronic inflammation. In this issue of Cell Chemical Biology, Peltner et al.¹ report that the cannabis component cannabidiol induces production of pro-resolving lipids directly activating 15-lipoxygenase and inhibiting 5-lipoxygenase in human macrophages.

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MeSH terms

Homeostasis
Humans
Inflammation*
Lipids
Macrophages*

Substances

Lipids