Synergistic effect of photothermal and magnetic hyperthermia for in situ activation of Fenton reaction in tumor microenvironment for chemodynamic therapy

Senthilkumar Thirumurugan; Pranjyan Dash; Yu-Chien Lin; Rajalakshmi Sakthivel; Ying-Sui Sun; Ching-Po Lin; An-Ni Wang; Xinke Liu; Udesh Dhawan; Ching-Wei Tung; Ren-Jei Chung

doi:10.1016/j.bioadv.2023.213724

Synergistic effect of photothermal and magnetic hyperthermia for in situ activation of Fenton reaction in tumor microenvironment for chemodynamic therapy

Biomater Adv. 2024 Feb:157:213724. doi: 10.1016/j.bioadv.2023.213724. Epub 2023 Dec 12.

Authors

Affiliations

¹ Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 106344, Taiwan.
² School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 110301, Taiwan.
³ Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
⁴ Scrona AG, Zürich 8045, Switzerland.
⁵ College of Materials Science and Engineering, Chinese Engineering and Research Institute of Microelectronics, Shenzhen University, Shenzhen 518060, China; Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore.
⁶ Centre for the Cellular Microenvironment, Division of Biomedical Engineering, James Watt School of Engineering, Mazumdar-Shaw Advanced Research Centre, University of Glasgow, Glasgow, G116EW, UK.
⁷ Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan. Electronic address: chingweitung@mail.mcut.edu.tw.
⁸ Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 106344, Taiwan; High-value Biomaterials Research and Commercialization Center, National Taipei University of Technology (Taipei Tech), Taipei 106344, Taiwan. Electronic address: rjchung@mail.ntut.edu.tw.

PMID: 38134729
DOI: 10.1016/j.bioadv.2023.213724

Abstract

Traditional cancer treatments are ineffective and cause severe adverse effects. Thus, the development of chemodynamic therapy (CDT) has the potential for in situ catalysis of endogenous molecules into highly toxic species, which would then effectively destroy cancer cells. However, the shortage of high-performance nanomaterials hinders the broad clinical application of this approach. In present study, an effective therapeutic platform was developed using a simple hydrothermal method for the in-situ activation of the Fenton reaction within the tumor microenvironment (TME) to generate substantial quantities of •OH and ultimately destroy cancer cells, which could be further synergistically increased by photothermal therapy (PHT) and magnetic hyperthermia (MHT) aided by FeMoO₄ nanorods (NRs). The produced FeMoO₄ NRs were used as MHT/PHT and Fenton catalysts. The photothermal conversion efficiency of the FeMoO₄ NRs was 31.75 %. In vitro and \ experiments demonstrated that the synergistic combination of MHT/PHT/CDT notably improved anticancer efficacy. This work reveals the significant efficacy of CDT aided by both photothermal and magnetic hyperthermia and offers a feasible strategy for the use of iron-based nanoparticles in the field of biomedical applications.

Keywords: Chemodynamic therapy; Magnetic hyperthermia therapy; Photothermal therapy; Tumor microenvironment.

MeSH terms

Hyperthermia, Induced*
Magnetic Phenomena
Nanostructures*
Phototherapy
Tumor Microenvironment