Conductive hydrogels have attracted much attention for their wide application in the field of flexible wearable sensors due to their outstanding flexibility, conductivity and sensing properties. However, the weak mechanical properties, lack of frost resistance and susceptibility to microbial contamination of traditional conductive hydrogels greatly limit their practical application. In this work, multifunctional polyvinyl alcohol (PVA)/carboxymethyl cellulose (CMC)/poly(acrylamide-co-1-vinyl-3-butylimidazolium bromide) (P(AAm-co-VBIMBr)) (PCPAV) ionic conductive hydrogels with high strength and good conductive, transparent, anti-freezing and antibacterial properties were constructed by introducing a network of chemically crosslinked AAm and VBIMBr copolymers into the base material of PVA and CMC by in situ free radical polymerization. Owing to the multiple interactions between the polymers, including covalent crosslinking, multiple hydrogen bonding interactions, and electrostatic interactions, the obtained ionic conductive hydrogels exhibit a high tensile strength (360.6 kPa), a large elongation at break (810.6%), good toughness, and fatigue resistance properties. The introduction of VBIMBr endows the PCPAV hydrogels with excellent transparency (∼92%), a high ionic conductivity (15.2 mS cm-1), antimicrobial activity and good flexibility and conductivity at sub-zero temperatures. Notably, the PCPAV hydrogels exhibit a wide strain range (0-800%), high strain sensitivity (GF = 3.75), fast response, long-term stability, and fantastic durability, which enable them to detect both large joint movements and minute muscle movements. Based on these advantages, it is believed that the PCPAV-based hydrogel sensors would have potential applications in health monitoring, human motion detection, soft robotics, ionic skins, human-machine interfaces, and other flexible electronic devices.