Natural foods resources and dietary ingredients for the amelioration of Helicobacter pylori infection

Chengyuan Wang; Meixiang Yao; Hongguang Zhong; Stephene S Meena; Fuxing Shu; Shaoping Nie; Mingyong Xie

doi:10.3389/fmed.2023.1324473

Natural foods resources and dietary ingredients for the amelioration of Helicobacter pylori infection

Front Med (Lausanne). 2023 Dec 6:10:1324473. doi: 10.3389/fmed.2023.1324473. eCollection 2023.

Authors

Chengyuan Wang¹, Meixiang Yao², Hongguang Zhong², Stephene S Meena³, Fuxing Shu⁴, Shaoping Nie¹, Mingyong Xie¹

Affiliations

¹ State Key Laboratory of Food Science and Technology, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang, Jiangxi, China.
² Jiangzhong Dietary Therapy Technology Co. Ltd, Jiujiang, Jiangxi, China.
³ Jiangzhong Cancer Research, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
⁴ College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, China.

Abstract

Helicobacter pylori (H. pylori) is a gastric-persistent pathogen that can cause peptic ulcer disease, gastric cancer, and mucosal-associated lymphoid tissue lymphoma. This pathogen is commonly treated with antibiotic-based triple or quadruple therapy. However, antibiotic therapy could result in the bacterial resistance, imbalance of gut microbiota, and damage to the liver and kidneys, etc. Therefore, there is an urgent need for alternative therapeutic strategies. Interestingly, natural food resources, like vegetables, fruits, spices, and edible herbs, have potent inhibitory effects on H. pylori. In this review, we systematically summarized these foods with supporting evidence from both animal and clinical studies. The results have indicated that natural foods may possess temporary inhibition effect on H. pylori rather than durable eradication, and may help to reduce H. pylori colonization, enhance the effect of antibiotics and modulate the host's immune response.

Keywords: Helicobacter pylori; antibiotics; dietatary ingredients; eradication; natural foods.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The financial supported by the Key Technological Project of Jiangxi Province (20212AAF01005).