Hippo pathway in intestinal diseases: focusing on ferroptosis

Hongwei Deng; Qiuting Jia; Xin Ming; Yuxin Sun; Yuxuan Lu; Li Liu; Jun Zhou

doi:10.3389/fcell.2023.1291686

Hippo pathway in intestinal diseases: focusing on ferroptosis

Front Cell Dev Biol. 2023 Dec 6:11:1291686. doi: 10.3389/fcell.2023.1291686. eCollection 2023.

Authors

Hongwei Deng^{1

2}, Qiuting Jia^{1

2}, Xin Ming^{2

3}, Yuxin Sun^{2

4}, Yuxuan Lu^{1

2}, Li Liu^{1

2

5}, Jun Zhou^{1

2

5}

Affiliations

¹ Department of Anesthesiology, Southwest Medical University, Luzhou, China.
² Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Luzhou, China.
³ School of Clinical Medicine, Southwest Medical University, Luzhou, China.
⁴ School of Basic Medicine, Southwest Medical University, Luzhou, China.
⁵ Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.

Abstract

The incidence of intestinal diseases, such as inflammatory bowel disease, gastric cancer, and colorectal cancer, has steadily increased over the past decades. The Hippo pathway is involved in cell proliferation, tissue and organ damage, energy metabolism, tumor formation, and other physiologic processes. Ferroptosis is a form of programmed cell death characterized by the accumulation of iron and lipid peroxides. The Hippo pathway and ferroptosis are associated with various intestinal diseases; however, the crosstalk between them is unclear. This review elaborates on the current research on the Hippo pathway and ferroptosis in the context of intestinal diseases. We summarized the connection between the Hippo pathway and ferroptosis to elucidate the underlying mechanism by which these pathways influence intestinal diseases. We speculate that a mutual regulatory mechanism exists between the Hippo pathway and ferroptosis and these two pathways interact in several ways to regulate intestinal diseases.

Keywords: Hippo pathway; crosstalk; ferroptosis; intestinal diseases; mechanisms.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was fully supported by the China International College Students’ Innovation and Entrepreneurship Competition (No. 202210632034) and the National Natural Science Foundation of China (No. 81873930) and partly supported by the Sichuan Science and Technology Program (No. 2022YFS0632) and Hejiang County People’s Hospital-Southwest Medical University Science and Technology Strategic Cooperation Project (No. 2021HJXNYD03).