Recent advances in polymeric microparticle-based drug delivery systems for knee osteoarthritis treatment

Guangxin Wang; Xin-An Zhang; Leonid Kapilevich; Mingjie Hu

doi:10.3389/fbioe.2023.1290870

Recent advances in polymeric microparticle-based drug delivery systems for knee osteoarthritis treatment

Front Bioeng Biotechnol. 2023 Dec 7:11:1290870. doi: 10.3389/fbioe.2023.1290870. eCollection 2023.

Authors

Guangxin Wang¹, Xin-An Zhang², Leonid Kapilevich³, Mingjie Hu²

Affiliations

¹ Department of Orthopedics, The Fourth People's Hospital of Shenyang, Shenyang, China.
² College of Exercise and Health, Shenyang Sport University, Shenyang, China.
³ Faculty of Physical Education, Nаtionаl Reseаrch Tomsk Stаte University, Tomsk, Russiа.

Abstract

Due to the poor bioavailability and high joint clearance of drugs, sustained delivery of therapeutic agents has proven difficult in the treatment of osteoarthritis (OA). Intra-articular (IA) drug delivery strategy is an attractive option for enhancing OA patients' prognosis, for which various polymer materials have been used as drug carriers due to their attractive delivery properties, to slow or even reverse the progress of OA by prolonging the duration of therapeutic agent residence in the joint. This article focuses on the recent developments in natural and synthetic polymer-based microsphere drug delivery systems for treating knee osteoarthritis. It evaluates the translational potential of some novel formulations for clinical application.

Keywords: biodegradable polymers; drug delivery systems; intra-articular; knee osteoarthritis; microparticles.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (32371184), Liaoning Province Applied Basic Research Program (2023JH2/101300072) and the Science and Technology Innovation Program of the General Administration of Sport of China (22KJCX040).