The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges

Ya-Nan Wei; Chun-Yan Yan; Meng-Lu Zhao; Xi-He Zhao

doi:10.1016/j.omto.2023.100752

The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges

Mol Ther Oncolytics. 2023 Nov 23:31:100752. doi: 10.1016/j.omto.2023.100752. eCollection 2023 Dec 19.

Authors

Ya-Nan Wei¹, Chun-Yan Yan¹, Meng-Lu Zhao¹, Xi-He Zhao¹

Affiliation

¹ Department of Clinical Oncology, Sheng jing Hospital of China Medical University, Shenyang 110022, People's Republic of China.

Abstract

Extracellular vesicles (EVs) carry DNA, RNA, protein, and other substances involved in intercellular crosstalk and can be used for the targeted delivery of drugs. Triple-negative breast cancer (TNBC) is rich in recurrent and metastatic disease and lacks therapeutic targets. Studies have proved the role of EVs in the different stages of the genesis and development of TNBC. Cancer cells actively secrete various biomolecules, which play a significant part establishing the tumor microenvironment via EVs. In this article, we describe the roles of EVs in the tumor immune microenvironment, metabolic microenvironment, and vascular remodeling, and summarize the application of EVs for objective delivery of chemotherapeutic drugs, immune antigens, and cancer vaccine adjuvants. EVs-based therapy may represent the next-generation tool for targeted drug delivery for the cure of a variety of diseases lacking effective drug treatment.

Keywords: Triple-negative breast cancer; drug resistance/biochemistry of membrane metabolism and transportion; liquid biopsy; tumor microenvironment/host-tumor interactions; vesicle.

Publication types

Review