Human-specific translational control of neuronal mitochondria and excitability

Alicia R Lane; Meghan E Wynne; Victor Faundez

doi:10.1016/j.neuron.2023.10.031

Human-specific translational control of neuronal mitochondria and excitability

Neuron. 2023 Dec 20;111(24):3901-3903. doi: 10.1016/j.neuron.2023.10.031.

Authors

Alicia R Lane¹, Meghan E Wynne¹, Victor Faundez²

Affiliations

¹ Department of Cell Biology, Emory University, Atlanta, GA 30322, USA.
² Department of Cell Biology, Emory University, Atlanta, GA 30322, USA. Electronic address: vfaunde@emory.edu.

PMID: 38128477
DOI: 10.1016/j.neuron.2023.10.031

Abstract

How are human-specific brain bioenergetics and excitability connected? In this Neuron issue, Shen et al.¹ reveal a human-specific interaction between RACK1 mRNA and FMRP. Reducing RACK1 mimics FMRP-dependent excitability and mitochondrial phenotypes, which can be reversed with mitochondrial-protective drugs. These findings suggest that FMRP-mediated translation adapts mitochondria to excitability energy demands.

MeSH terms

Fragile X Mental Retardation Protein* / genetics
Humans
Neurons* / physiology
RNA, Messenger / genetics

Substances

Fragile X Mental Retardation Protein
RNA, Messenger