The significance of the omentum in locoregional immunotherapy for peritoneal carcinomatosis

Ángela Bella; Ignacio Melero; Pedro Berraondo; Fernando Aranda

doi:10.1080/2162402X.2023.2285106

The significance of the omentum in locoregional immunotherapy for peritoneal carcinomatosis

Oncoimmunology. 2023 Nov 20;12(1):2285106. doi: 10.1080/2162402X.2023.2285106. eCollection 2023.

Authors

Ángela Bella^{1

2}, Ignacio Melero^{1

2

3

4

5}, Pedro Berraondo^{1

2

3}, Fernando Aranda^{1

2}

Affiliations

¹ Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
² Navarra Institute for Health Research (IDISNA), Pamplona, Spain.
³ Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
⁴ Department of Oncology and Department of Immunology and Immunotherapy, Clínica Universidad de Navarra, Pamplona, Spain.
⁵ Nuffield Department of Medicine and Oxford Center for Immuno-Oncology, University of Oxford, Oxford, UK.

Abstract

Our recent research has unveiled the potential of locoregional immunotherapy. Cytokine-armored viral vectors, such as modified vaccinia virus Ankara vector encoding single-chain interleukin-12 (MVA.scIL-12), can target the omentum and elicit a robust tumor-specific immune response, all the while minimizing toxicity.

Keywords: Adoptive cell transfer; locoregional immunotherapy; omentum; peritoneal carcinomatosis; virotherapy.

MeSH terms

Genetic Vectors
Humans
Immunotherapy / adverse effects
Omentum
Peritoneal Neoplasms* / therapy
Vaccinia virus* / genetics

Grants and funding

Authors are supported by Bavarian Nordic, Instituto de Salud Carlos III (PI22/00147, PI20/00002, PI23/00203) co-financed by Fondos Feder, Gobierno de Navarra Proyecto ARNMUNE Ref.: 0011–1411-2023. F.A. receives a Miguel Servet I (CP19/00114) contract from ISCIII (Instituto de Salud Carlos III) co-financed by FSE (Fondo Social Europeo). A.B. is the recipient of PFIS fellowship from ISCIII (FI20/00058). Work produced with the support of a 2022 Leonardo Grant for Researchers and Cultural Creators (BBVA Foundation).