Non-linear associations of maternal pre-pregnancy body mass index with risk of stillbirth, infant, and neonatal mortality in over 28 million births in the USA: a retrospective cohort study

Hannah V Thornton; Rosie P Cornish; Deborah A Lawlor

doi:10.1016/j.eclinm.2023.102351

Non-linear associations of maternal pre-pregnancy body mass index with risk of stillbirth, infant, and neonatal mortality in over 28 million births in the USA: a retrospective cohort study

EClinicalMedicine. 2023 Dec 2:66:102351. doi: 10.1016/j.eclinm.2023.102351. eCollection 2023 Dec.

Authors

Hannah V Thornton¹, Rosie P Cornish^{1

2}, Deborah A Lawlor^{1

2

3}

Affiliations

¹ Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
² MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
³ Bristol National Institute for Health Research Biomedical Research Centre, University of Bristol, Bristol, UK.

Abstract

Background: Higher maternal pre-pregnancy body mass index (BMI) has been associated with higher risk of stillbirth, infant and neonatal mortality. Studies exploring underweight have varied in their conclusions. Our aim was to examine the risk of stillbirth, infant and neonatal mortality across the BMI distribution and establish a likely healthy BMI range.

Methods: In this retrospective cohort study, we used publicly available datasets (covering 1st January 2014 to 31st December 2021) from the US National Center for Health Statistics National Vital Statistics System. All births were eligible; analyses included those with non-missing data. Fractional polynomial multivariable logistic regression was used to examine the associations of maternal pre-pregnant BMI with stillbirth (birth with no signs of life at ≥24 weeks), infant mortality (death of a live born baby aged <365 days) and neonatal mortality (death of a live born baby aged <28 days).

Findings: There were 77,896/28,310,154 (2.8 per 1000 births) stillbirths, 143,620/28,231,807 (5.1 per 1000 live births) infant deaths and 94,246/28,231,807 (3.3 per 1000 live births) neonatal deaths among complete cases. Mean (SD) BMI was 27.1 kg/m² (6.7 kg/m²). We found non-linear associations between BMI and all three outcomes; risk was elevated at both low and high BMIs although, for stillbirth, the increased risk at low BMI was less marked than for infant/neonatal mortality. The lowest risk was at a BMI of 21 kg/m² for infant and neonatal mortality and 19 kg/m² for stillbirth.

Interpretation: Public health messaging for preconception and postnatal care should focus on healthy weight to maximise maternal and child health, and not focus solely on maternal overweight or obesity.

Funding: European Research Council, US National Institute of Health, UK Medical Research Council and National Institute for Health and Care Research.

Keywords: Body mass index; Infant mortality; Neonatal mortality; Stillbirth.