Reactive Keratoacanthoma Following Treatment with 5-Fluorouracil

Komal A Paradkar; Alisha N Plotner

Reactive Keratoacanthoma Following Treatment with 5-Fluorouracil

J Clin Aesthet Dermatol. 2023 Dec;16(12):55-56.

Authors

Komal A Paradkar¹, Alisha N Plotner²

Affiliations

¹ Ms. Paradkar is with The Ohio State University College of Medicine in Columbus, Ohio.
² Dr. Plotner is with Division of Dermatology, The Ohio State University in Columbus, Ohio.

PMID: 38125667
PMCID: PMC10729802

Abstract

Keratoacanthoma (KA) is an epidermal cell tumor with a central keratin plug known to be a variant of keratinocyte carcinoma (KC). KAs typically arise from ultraviolet (UV)-damaged skin and thus are particularly prevalent on extremities. KAs can also be a consequence of local skin trauma. 5-fluorouracil (5-FU) is a topical therapy used to treat early KC, as well as actinic keratoses (AKs). In this paper, we describe the unique cases of two elderly female patients who were treated with 5-FU for AKs of the lower extremities but developed severe inflammatory reactions and reactive KAs to the topical therapy.

Keywords: 5-fluorouracil; Keratoacanthoma; keratinocyte carcinoma; reactive keratoacanthoma.

Publication types

Case Reports