C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect

Lucas Schoenauen; François-Xavier Stubbe; Dirk Van Gestel; Sébastien Penninckx; Anne-Catherine Heuskin

doi:10.1016/j.ctro.2023.100712

C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect

Clin Transl Radiat Oncol. 2023 Dec 9:45:100712. doi: 10.1016/j.ctro.2023.100712. eCollection 2024 Mar.

Authors

Lucas Schoenauen¹, François-Xavier Stubbe¹, Dirk Van Gestel², Sébastien Penninckx², Anne-Catherine Heuskin¹

Affiliations

¹ NAmur Research Insitute for Life Sciences, University of Namur, Belgium.
² Department of Radiation Oncology, Institut Jules Bordet, Hopital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Brussels, Belgium.

Abstract

This study explores the effects of UHDR irradiation on Caenorhabditis elegans embryos. UHDR proton and electron beams demonstrate a sparing effect, aligning with literature findings. This highlights C. elegans suitability as a screening model for studying the LET impact on the FLASH effect, reinforcing its potential in radiation research.

Keywords: C. elegans embryo; Electron flash; Proton flash.