Dominant-negative effect of lactase missense variants: hetero-complex assembly with the wild-type enzyme impairs intracellular trafficking and digestive function

Affiliations

• ¹ Department of Biochemistry, University of Veterinary Medicine Hannover, Hannover, Germany.
• ² Department of Pediatrics and Adolescent Medicine, University Medical Center Göttingen, Göttingen, Germany.
• ³ Department of Pediatrics, University Medical Center Eppendorf, Hamburg, Germany.
• ⁴ Department of Biochemistry, University of Veterinary Medicine Hannover, Hannover, Germany Hassan.Naim@tiho-hannover.de.