Mesenchymal stem cell therapy for COVID-19 infection

Seyyed Mohammad Matin Alavi-Dana; Yazdan Gholami; Mohammadreza Meghdadi; Mohammad Saleh Fadaei; Vahid Reza Askari

doi:10.1007/s10787-023-01394-8

Mesenchymal stem cell therapy for COVID-19 infection

Inflammopharmacology. 2024 Feb;32(1):319-334. doi: 10.1007/s10787-023-01394-8. Epub 2023 Dec 20.

Authors

Seyyed Mohammad Matin Alavi-Dana¹, Yazdan Gholami¹, Mohammadreza Meghdadi², Mohammad Saleh Fadaei³, Vahid Reza Askari^{4

5

6}

Affiliations

¹ Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
² Department of Hematology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Azadi Sq, Vakil Abad Highway, Mashhad, 9177948564, Iran.
⁴ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Azadi Sq, Vakil Abad Highway, Mashhad, 9177948564, Iran. askariv@mums.ac.ir.
⁵ Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran. askariv@mums.ac.ir.
⁶ International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. askariv@mums.ac.ir.

PMID: 38117433
DOI: 10.1007/s10787-023-01394-8

Abstract

COVID-19 emerged in December 2019 in Wuhan, China, spread worldwide rapidly, and caused millions of deaths in a short time. Many preclinical and clinical studies were performed to discover the most efficient therapy to reduce the mortality of COVID-19 patients. Among various approaches for preventing and treating COVID-19, mesenchymal stem cell (MSC) therapy can be regarded as a novel and efficient treatment for managing COVID-19 patients. In this review, we explain the pathogenesis of COVID-19 infection in humans and discuss the role of MSCs in suppressing the inflammation and cytokine storm produced by COVID-19. Then, we reviewed the clinical trial and systematic review studies that investigated the safety and efficacy of MSC therapy in the treatment of COVID-19 infection.

Keywords: COVID-19; Cytokine; Fibrosis; Infection; Inflammation; Mesenchymal stem cells.

Publication types

Review

MeSH terms

COVID-19* / therapy
Cytokine Release Syndrome
Humans
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells*
Systematic Reviews as Topic