Range adaptation in schizophrenia: A one-year longitudinal study

Ling-Ling Wang; Jing-Bo Gong; Yi-Hang Huang; Shu-Hong Shi; Chao Yan; Hui-Xin Hu; Yi Wang; Simon S Y Lui; Kang Ju; Raymond C K Chan

doi:10.1016/j.scog.2023.100297

Range adaptation in schizophrenia: A one-year longitudinal study

Schizophr Res Cogn. 2023 Nov 30:35:100297. doi: 10.1016/j.scog.2023.100297. eCollection 2024 Mar.

Authors

Ling-Ling Wang^{1

2

3}, Jing-Bo Gong⁴, Yi-Hang Huang^{2

3}, Shu-Hong Shi^{4

5}, Chao Yan^{4

5}, Hui-Xin Hu^{2

3

6}, Yi Wang^{2

3}, Simon S Y Lui⁷, Kang Ju⁴, Raymond C K Chan^{2

3}

Affiliations

¹ School of Psychology, Shanghai Normal University, Shanghai, China.
² Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
³ Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
⁴ Shanghai Changning Mental Health Center, Shanghai, China.
⁵ Key Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU Mental Health Center, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.
⁶ Department of Psychology, School of Humanities and Social Sciences, Beijing Forestry University, Beijing, China.
⁷ Department of Psychiatry, School of Clinical Medicine, The University of Hong Kong, Hong Kong.

Abstract

Range adaptation refers to the representation of a stimulus value based on its relative position in the range of pre-experienced values. Altered range adaptation in value representation may be related to motivation and pleasure (MAP) deficit in schizophrenia (SCZ). This follow-up study examined the relationship between range adaptation performance and MAP symptoms in SCZ patients. We recruited 26 schizophrenia patients and followed them for 1 year. They completed an experimental task for estimating their range adaptation to outcome value (OV) and expected value (EV) at baseline and after 1 year. At baseline, we found a marginally significant and negative correlation between OV adaptation and avolition symptoms in SCZ patients. Moreover, the 1-year change of EV adaptation was significantly and negatively correlated with the change of self-report pleasure experience. Our results suggest that range adaptation may track the variations of MAP symptoms in SCZ.

Keywords: Amotivation; Anhedonia; Longitudinal; Range adaptation; Schizophrenia.