Objective: To investigate the relationship between dietary vitamin E(VE) intake and mild cognitive impairment(MCI).
Methods: Based on the data of Hebei Province in the 2018 National Key Research and Development Program Nervous system disease CCSNSD, 612 subjects were included in this study. All study participants were surveyed for dietary VE intake by the Dietary Frequency Questionnaire and assessed for cognitive function by the Montreal Cognitive Assessment Scale. The relationship between dietary VE intake and MCI and its subtypes was analyzed using logistic regression and restricted cubic splines.
Results: The study subjects included 260(42.5%) males and 352(57.5%) females, with an average age of(66.8±7.4) years and an average dietary VE intake of(12.17±4.91) mg/d. The prevalence of cognitive impairment in the study population was 41.3%. After adjusting the covariates of age, gender, energy intake, residence, education level, employment status, BMI, smoking, drinking, physical activity, hypertension, diabetes, VE intake was not associated with the risk of non-amnesic(naMCI), single-domain amnesic(aMCI-SD), but relate to the risk of multi-domain amnesic(aMCI-MD). What's more, compared to dietary vitamin E intake Q1 group, the OR(95%CI) for multi-domain amnesic mild cognitive impairment in Q2, Q3 and Q4 groups were 1.628(0.836-3.170), 0.313(0.124-0.791) and 0.727(0.330-1.602), respectively. Using vitamin E intake as a continuous-type variable, a non-linear dose-response relationship was found between VE intake and mild cognitive dysfunction of the multi-domain amnesic type(P=0.02). When VE intake was about 17 mg/d, the risk of aMCI-MD was the lowest.
Conclusion: There is an approximate "U" shaped dose-response relationship between dietary VE intake and the risk of mild cognitive impairment with multi-domain amnesia type. Research suggests that moderate VE intake has a preventive effect on the development of mild cognitive impairment.
Keywords: Logistic regression; dietary intake; mild cognitive impairment; restricted cubic spline; subtypes of mild cognitive impairment; vitamin E.