Ulcerative colitis coexisting with hepatitis C: A rare occurrence

Medicine (Baltimore). 2023 Dec 15;102(50):e36629. doi: 10.1097/MD.0000000000036629.

Abstract

Introduction: We describe a rare case of a 54-year-old male diagnosed with both ulcerative colitis (UC) and hepatitis C virus (HCV), posing clinical challenges.

Patient concerns: The patient showed worsened UC symptoms, leading to further evaluations.

Diagnosis: Dual diagnosis of UC and HCV was confirmed through endoscopy and serological tests, ruling out other hepatic causes. Interventions: Treatment involved methylprednisolone for UC and sofosbuvir/velpatasvir for HCV, with attention to drug interactions.

Outcomes: Significant improvement was observed in both UC symptoms and HCV viral load post-treatment.

Conclusion: This case underscores the need for nuanced treatment in managing concurrent UC and HCV, considering potential drug interactions and disease impacts.

Publication types

  • Case Reports

MeSH terms

  • Antiviral Agents / therapeutic use
  • Colitis, Ulcerative* / complications
  • Colitis, Ulcerative* / drug therapy
  • Genotype
  • Hepacivirus
  • Hepatitis C* / complications
  • Hepatitis C* / drug therapy
  • Hepatitis C, Chronic* / complications
  • Hepatitis C, Chronic* / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Sofosbuvir / therapeutic use
  • Treatment Outcome

Substances

  • Antiviral Agents
  • Sofosbuvir