Systematic review and integrated analysis of prognostic gene signatures for prostate cancer patients

Yang An; Wenyuan Lu; Shijia Li; Xiaoyan Lu; Yuanyuan Zhang; Dongcheng Han; Dingyuan Su; Jiaxin Jia; Jiaxin Yuan; Binbin Zhao; Mengjie Tu; Xinyu Li; Xiaoqing Wang; Na Fang; Shaoping Ji

doi:10.1007/s12672-023-00847-4

Systematic review and integrated analysis of prognostic gene signatures for prostate cancer patients

Discov Oncol. 2023 Dec 19;14(1):234. doi: 10.1007/s12672-023-00847-4.

Authors

Yang An^{1

2

3}, Wenyuan Lu^{4

5

6}, Shijia Li^{4

5

6}, Xiaoyan Lu^{4

5

6}, Yuanyuan Zhang^{4

5

6}, Dongcheng Han^{4

5

6}, Dingyuan Su^{4

5

6}, Jiaxin Jia^{4

5

6}, Jiaxin Yuan^{4

5

6}, Binbin Zhao^{4

5

6}, Mengjie Tu^{4

5

6}, Xinyu Li^{4

5

6}, Xiaoqing Wang^{4

5

6}, Na Fang^{7

8

9}, Shaoping Ji^{10

11

12}

Affiliations

¹ School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China. anyang@henu.edu.cn.
² Department of Biochemistry and Molecular Biology, Cell Signal Transduction Laboratory, School of Basic Medical Sciences, Henan University, Jinming Street, Kaifeng, 475004, Henan, China. anyang@henu.edu.cn.
³ Henan Provincial Engineering Center for Tumor Molecular Medicine, Kaifeng Key Laboratory of Cell Signal Transduction, Kaifeng, 475004, China. anyang@henu.edu.cn.
⁴ School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
⁵ Department of Biochemistry and Molecular Biology, Cell Signal Transduction Laboratory, School of Basic Medical Sciences, Henan University, Jinming Street, Kaifeng, 475004, Henan, China.
⁶ Henan Provincial Engineering Center for Tumor Molecular Medicine, Kaifeng Key Laboratory of Cell Signal Transduction, Kaifeng, 475004, China.
⁷ School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China. fangna@vip.henu.edu.cn.
⁸ Department of Biochemistry and Molecular Biology, Cell Signal Transduction Laboratory, School of Basic Medical Sciences, Henan University, Jinming Street, Kaifeng, 475004, Henan, China. fangna@vip.henu.edu.cn.
⁹ Henan Provincial Engineering Center for Tumor Molecular Medicine, Kaifeng Key Laboratory of Cell Signal Transduction, Kaifeng, 475004, China. fangna@vip.henu.edu.cn.
¹⁰ School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China. shaopingji@henu.edu.cn.
¹¹ Department of Biochemistry and Molecular Biology, Cell Signal Transduction Laboratory, School of Basic Medical Sciences, Henan University, Jinming Street, Kaifeng, 475004, Henan, China. shaopingji@henu.edu.cn.
¹² Henan Provincial Engineering Center for Tumor Molecular Medicine, Kaifeng Key Laboratory of Cell Signal Transduction, Kaifeng, 475004, China. shaopingji@henu.edu.cn.

Abstract

Prostate cancer (PC) is one of the most common cancers in men and becoming the second leading cause of cancer fatalities. At present, the lack of effective strategies for prognosis of PC patients is still a problem to be solved. Therefore, it is significant to identify potential gene signatures for PC patients' prognosis. Here, we summarized 71 different prognostic gene signatures for PC and concluded 3 strategies for signature construction after extensive investigation. In addition, 14 genes frequently appeared in 71 different gene signatures, which enriched in mitotic and cell cycle. This review provides extensive understanding and integrated analysis of current prognostic signatures of PC, which may help researchers to construct gene signatures of PC and guide future clinical treatment.

Keywords: Biomarker; Gene signature; Prognosis; Prostate cancer; Survival.

Abstract

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