Biopharmaceutical products are currently well-established in nearly all branches of medicine and are believed to have great potential for the treatment of a broad spectrum of diseases. Peptide/protein drugs exhibit a predominant class of new biopharmaceuticals coming on the market in recent years. Oral delivery of peptides/proteins as a non-invasive therapeutic technique has become an appealing alternative to the parenteral route. However, the efficient oral delivery of peptides/proteins is limited because of their high molecular weight, poor stability and low biodistribution. Nanoparticles (NPs) have shown excellent results in peptide/protein delivery research. In this paper, the use of NPs as delivery systems for peptides/proteins and their ability to be efficiently delivered via the oral route have been described.
Keywords: biopharmaceuticals; cells; nanoparticles; oral delivery; peptides; proteins.
Medicines made from peptides and proteins have become important for treating various diseases. One challenge is delivering them effectively through the mouth, as they can be fragile and may not distribute well in the body. Scientists have been studying the use of tiny particles called nanoparticles (NPs) to help solve these problems. In this article, we explore how NPs can enhance the delivery of peptide/protein medicines when taken orally. By using NPs as delivery platforms, these medicines can be protected and absorbed more efficiently, leading to better treatment outcomes.