First case report of Candida guilliermondii native left-sided valve endocarditis

Zilong Zheng; Xiaokang Tu; Chuanhao Jiang; Feng Liu; Chengming Fan

doi:10.3389/fcvm.2023.1273255

First case report of Candida guilliermondii native left-sided valve endocarditis

Front Cardiovasc Med. 2023 Dec 4:10:1273255. doi: 10.3389/fcvm.2023.1273255. eCollection 2023.

Authors

Zilong Zheng¹, Xiaokang Tu¹, Chuanhao Jiang², Feng Liu¹, Chengming Fan¹

Affiliations

¹ Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
² Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

Abstract

Endocarditis, a life-threatening inflammation of the endocardium, is incited by bacteria, fungi, or other pathogenic microorganisms. Fungal endocarditis closely mirrors bacterial endocarditis in clinical signs and symptoms, leading to potential misdiagnoses. Here, we unveil the inaugural confirmed instance of native left-sided valve endocarditis attributed to Candida guilliermondii. Diagnosis was substantiated through valvular biopsies, blood and vegetative cultures. Treatment encompassed surgical excision of vegetations along with a six-week regimen of fluconazole administration (12 mg/kg/day), followed by 4 years of meticulous monitoring, resulting in sustained patient recovery.

Keywords: Candida guilliermondii; aortic valve; cardiac surgery; fungal endocarditis; infective endocarditis; mitral valve.

Publication types

Case Reports

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article.