Global research trends and prospects related to tumor microenvironment within Triple Negative Breast Cancer: a bibliometric analysis

Peiting Li; Jun Li; Xiaofei Tong; Zhenyang Xiao; Wuliang Diao; Chi Zhong; Jianda Zhou; Wei Wu

doi:10.3389/fimmu.2023.1261290

Global research trends and prospects related to tumor microenvironment within Triple Negative Breast Cancer: a bibliometric analysis

Front Immunol. 2023 Dec 4:14:1261290. doi: 10.3389/fimmu.2023.1261290. eCollection 2023.

Authors

Peiting Li¹, Jun Li², Xiaofei Tong¹, Zhenyang Xiao¹, Wuliang Diao¹, Chi Zhong¹, Jianda Zhou¹, Wei Wu²

Affiliations

¹ Department of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
² Department of Breast Thyroid Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.

Abstract

Background and aims: The tumor microenvironment (TME) has pivotal parts within multiple tumor models of onset/progression, such as triple-negative breast cancer (TNBC). This bibliometric analysis was developed to explore trends and research niches revolving around TME in TNBC.

Methods: Web of Science Core Collection was queried for identifying studies linked with TME in TNBC, after which the VOSviewer, CiteSpace, and R software programs were used to conduct bibliometric analyses and to generate corresponding visualizations.

Results: In total, this study included 1,604 studies published from 2005-2023. The USA and China exhibited the highest numbers of citations, and the research institutions with the greatest output in this field included Harvard University, the University of Texas System, and Fudan University. Ying Wang from Sun Yat-Sen University was the most published and most cited author in this space. The highest number of articles were published in Cancer, while the greatest co-citation number was evident in Breast Cancer Research. Important keywords related to this research topic included metastasis, tumor-infiltrating lymphocytes, immunotherapy, chemotherapy, and nanoparticles. In particular, pembrolizumab, immunotherapy, nanoparticles, combination treatment, and biomarkers were topics of marked interest in recent reports.

Conclusion: The TME in TNBC is an area of rapidly growing and evolving research interest, with extensive global collaboration helping to drive this field forward. Antitumor therapies targeting the TME in TNBC patients represent an emerging topic of future research, providing opportunities for translational findings. The results of this analysis may provide additional guidance for work focused on the TME in TNBC.

Keywords: CiteSpace; Triple Negative Breast Cancer; VOSviewer; WoSCC; bibliometric analysis; tumor microenvironment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bibliometrics
Breast
China
Humans
Triple Negative Breast Neoplasms* / therapy
Tumor Microenvironment

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (No. 81872219) and Natural Science Foundation of Hunan Province, China (No. 2022JJ40748).