Receptor modulators associated with the hypothalamus -pituitary-thyroid axis

Xianbin Cheng; Hong Zhang; Shanshan Guan; Qi Zhao; Yaming Shan

doi:10.3389/fphar.2023.1291856

Receptor modulators associated with the hypothalamus -pituitary-thyroid axis

Front Pharmacol. 2023 Dec 4:14:1291856. doi: 10.3389/fphar.2023.1291856. eCollection 2023.

Authors

Xianbin Cheng^#^{1

2

3}, Hong Zhang^#², Shanshan Guan⁴, Qi Zhao⁵, Yaming Shan^{1

6}

Affiliations

¹ National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, China.
² Department of Thyroid Surgery, The Second Hospital of Jilin University, Changchun, China.
³ Postdoctoral Research Workstation, Changchun Gangheng Electronics Company Limited, Changchun, China.
⁴ College of Biology and Food Engineering, Jilin Engineering Normal University, Changchun, China.
⁵ Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, China.
⁶ Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, School of Life Sciences, Jilin University, Changchun, China.

^# Contributed equally.

Abstract

The hypothalamus-pituitary-thyroid (HPT) axis maintains normal metabolic balance and homeostasis in the human body through positive and negative feedback regulation. Its main regulatory mode is the secretion of thyrotropin (TSH), thyroid hormones (TH), and thyrotropin-releasing hormone (TRH). By binding to their corresponding receptors, they are involved in the development and progression of several systemic diseases, including digestive, cardiovascular, and central nervous system diseases. The HPT axis-related receptors include thyrotropin receptor (TSHR), thyroid hormone receptor (TR), and thyrotropin-releasing hormone receptor (TRHR). Recently, research on regulators has become popular in the field of biology. Several HPT axis-related receptor modulators have been used for clinical treatment. This study reviews the developments and recent findings on HPT axis-related receptor modulators. This will provide a theoretical basis for the development and utilisation of new modulators of the HPT axis receptors.

Keywords: HPT; agonist; antagonist; modulator; receptor.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The current work was supported by Department of Science and Technology of Jilin Province (Grant number: 20210204197YY), Changchun Science and Technology Bureau (Grant number: 21ZY15).