Eosinophil Distribution in Eosinophilic Esophagitis and its Impact on Disease Activity and Response to Treatment

Anne Godat; Ralph Mueller; Désirée Schenker; Alain M Schoepfer; Alex Straumann; Thomas Greuter; EoE Eosinophil Distribution Research Group

doi:10.1016/j.cgh.2023.12.003

Eosinophil Distribution in Eosinophilic Esophagitis and its Impact on Disease Activity and Response to Treatment

Clin Gastroenterol Hepatol. 2023 Dec 16:S1542-3565(23)01032-7. doi: 10.1016/j.cgh.2023.12.003. Online ahead of print.

Authors

Anne Godat¹, Ralph Mueller², Désirée Schenker³, Alain M Schoepfer⁴, Alex Straumann³, Thomas Greuter⁵; EoE Eosinophil Distribution Research Group

Collaborators

EoE Eosinophil Distribution Research Group:
Philipp Schreiner⁶, Luc Biedermann⁷, Dagmar Simon⁸, Hans-Uwe Simon⁹

Affiliations

¹ Department of Internal Medicine, GZO Zurich Regional Health Center, Wetzikon, Switzerland.
² Department of Clinical Research, Dr. Falk Pharma GmbH, Freiburg, Germany.
³ Department of Gastroenterology & Hepatology, University Hospital Zurich, Zurich, Switzerland.
⁴ Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
⁵ Department of Internal Medicine, GZO Zurich Regional Health Center, Wetzikon, Switzerland; Department of Gastroenterology & Hepatology, University Hospital Zurich, Zurich, Switzerland; Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. Electronic address: th_greuter@bluewin.ch.
⁶ Department of Gastroenterology & Hepatology, University Hospital Zurich, Zurich, Switzerland; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
⁷ Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
⁸ Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.
⁹ Institute of Pharmacology, University of Bern, Bern, Switzerland; Institute of Biochemistry, Brandenburg Medical School, Neuruppin, Germany.

PMID: 38110063
DOI: 10.1016/j.cgh.2023.12.003

Abstract

Although mostly accentuated in the distal esophagus, distribution of esophageal eosinophilia in eosinophilic esophagitis (EoE) seems to be nonuniform.¹ Disease extent has been associated with disease severity and disease progression in inflammatory bowel disease.^2,3 Whether the same holds true for EoE remains largely unknown. One recent EoE study looked at the distribution of eosinophilia, but without analyzing its potential association with treatment outcomes.⁴ Here, we characterize the different inflammatory patterns of EoE and investigate their impact on disease presentation and disease outcome, with a particular focus on therapeutic response.