Association Between Combined Polymetallic Exposure and Osteoporosis

Lidong Qin; Qiumei Liu; Tiantian Zhang; Xu Tang; Xiaoting Mo; Yujian Liang; Xuexiu Wang; Jiejing Cao; Chuwu Huang; Yufu Lu; Zhiyong Zhang; Jian Qin; Jiansheng Cai

doi:10.1007/s12011-023-04002-6

Association Between Combined Polymetallic Exposure and Osteoporosis

Biol Trace Elem Res. 2023 Dec 18. doi: 10.1007/s12011-023-04002-6. Online ahead of print.

Authors

Lidong Qin¹, Qiumei Liu¹, Tiantian Zhang¹, Xu Tang¹, Xiaoting Mo¹, Yujian Liang¹, Xuexiu Wang¹, Jiejing Cao¹, Chuwu Huang¹, Yufu Lu¹, Zhiyong Zhang^{1

2

3}, Jian Qin^{4

5

6

7}, Jiansheng Cai^{8

9}

Affiliations

¹ Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.
² Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin, China.
³ Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care, Guilin Medical University, Guilin, China.
⁴ Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China. qinjian@gxmu.edu.cn.
⁵ Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China. qinjian@gxmu.edu.cn.
⁶ Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, China. qinjian@gxmu.edu.cn.
⁷ Key Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education, Guangxi Medical University, Nanning, China. qinjian@gxmu.edu.cn.
⁸ Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China. 15007714226@163.com.
⁹ Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Huan Cheng North 2Nd Road 109, Guilin, 541004, Guangxi, China. 15007714226@163.com.

PMID: 38109003
DOI: 10.1007/s12011-023-04002-6

Abstract

Combined polymetallic exposure may be an influential factor in osteoporosis. This study aimed to explore the association between polymetallic combined exposure and osteoporosis. A total of 2115 participants were included. Plasma concentrations of 22 metals were determined by inductively coupled plasma mass spectrometry. Osteoporosis was defined as a T ≤ - 2.5. The least absolute shrinkage and selection operator (LASSO) regression, binary logistics regression, and Bayesian kernel machine regression (BKMR) model were used to explore the association between plasma metals and osteoporosis. LASSO regression showed that 10 metals were associated with osteoporosis in the total population (magnesium, calcium, manganese, nickel, cobalt, arsenic, selenium, rubidium, cadmium, aluminum) and women (magnesium, calcium, molybdenum, nickel, cobalt, arsenic, selenium, rubidium, cadmium, aluminum), and four metals associated with men (magnesium, cobalt, aluminum, iron). Logistics regression showed that in total population, magnesium (OR_Q3 = 0.653, 95% CI = 0.446-0.954) was negatively correlated with osteoporosis, while aluminum (OR_Q2 = 1.569, 95% CI = 1.095-2.248, OR_Q4 = 1.616, 95% CI = 1.109-2.354) and cadmium (OR_Q4 = 1.989, 95% CI = 1.379-2.870) were positively correlated; in women, magnesium (OR_Q3 = 0.579, 95% CI = 0.379-0.883) was negatively correlated with osteoporosis, while aluminum (OR_Q2 = 1.563, 95% CI = 1.051-2.326, OR_Q4 = 1.543, 95% CI = 1.024-2.326) and cadmium (OR_Q3 = 1.482, 95% CI = 1.003-2.191, OR_Q4 = 1.740, 95% CI = 1.167-2.596) were positively correlated. BKMR model showed that combined polymetallic exposure had an overall positive effect on osteoporosis, magnesium was negatively associated with osteoporosis, and cadmium, selenium, and aluminum were positively associated with osteoporosis. Metal mixtures in plasma were associated with osteoporosis risk. Magnesium may reduce the risk of osteoporosis, while cadmium, selenium, and aluminum may increase the risk of osteoporosis. Future studies needed to explore correlations and mechanisms.

Keywords: Aluminum; Bayesian kernel machine regression; Cadmium; Magnesium; Osteoporosis; Plasma metal mixture.

Abstract

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