The biological role of lncRNAs in the acute lymphocytic leukemia: An updated review

Hossein Ghahramani Almanghadim; Bahareh Karimi; Negareh Poursalehi; Melika Sanavandi; Sina Atefi Pourfardin; Kamran Ghaedi

doi:10.1016/j.gene.2023.148074

The biological role of lncRNAs in the acute lymphocytic leukemia: An updated review

Gene. 2024 Mar 10:898:148074. doi: 10.1016/j.gene.2023.148074. Epub 2023 Dec 15.

Authors

Hossein Ghahramani Almanghadim¹, Bahareh Karimi², Negareh Poursalehi³, Melika Sanavandi⁴, Sina Atefi Pourfardin⁵, Kamran Ghaedi⁶

Affiliations

¹ Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IR Iran.
² Department of Cellular and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
³ Department of Medical Biotechnology, School of Medicine Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
⁴ Physics Department, Shahid Beheshti University, Tehran, Iran.
⁵ Department of Biological Science, Ahar Branch, Islamic Azad University, Ahar, Iran.
⁶ Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Hezar Jerib Ave., Azadi Sq., 81746-73441 Isfahan, Iran. Electronic address: Kamranghaedi@yahoo.com.

PMID: 38104953
DOI: 10.1016/j.gene.2023.148074

Abstract

The cause of leukemia, a common malignancy of the hematological system, is unknown. The structure of long non-coding RNAs (lncRNAs) is similar to mRNA but no ability to encode proteins. Numerous malignancies, including different forms of leukemia, are linked to Lnc-RNAs. It is verified that the carcinogenesis and growth of a variety of human malignancies are significantly influenced by aberrant lncRNA expression. The body of evidence linking various types of lncRNAs to the etiology of leukemia has dramatically increased during the past ten years. Some lncRNAs are therefore anticipated to function as novel therapeutic targets, diagnostic biomarkers, and clinical outcome predictions. Additionally, these lncRNAs may provide new therapeutic options and insight into the pathophysiology of diseases, particularly leukemia. Thus, this review outlines the present comprehension of leukemia-associated lncRNAs.

Keywords: Acute lymphocytic leukemia; Long non-coding RNAs.

Publication types

Review

MeSH terms

Carcinogenesis / genetics
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism

Substances

RNA, Long Noncoding