Cytotoxic depsidones and xanthones from Garcinia esculenta Y. H. Li

Fitoterapia. 2024 Jan:172:105779. doi: 10.1016/j.fitote.2023.105779. Epub 2023 Dec 15.

Abstract

Six new compounds, including two depsidones garciculendepsidones A and B (1 and 2), one prenylated xanthone garciculenxanthone (3) and three dimeric xanthones bigarciculenxanthones A-C (4-6), were isolated from the twigs and leaves of Garcinia esculenta Y. H. Li. Their structures were elucidated based on comprehensive analyses of spectral data, including HRESIMS, 1D and 2D NMR, and ECD calculation. All the isolates were tested for their cytotoxicity against five human cancer cell lines (myeloid leukemia HL-60, lung cancer A-549 cells, hepatocellular carcinoma SMMC-7721, breast cancer MDA-MB-231 and colon cancer SW480), among them, compounds 3-5 displayed cytotoxic potential, especially garciculenxanthone (3) had the lowest IC50 value of 8.2 μm for lung cancer A-549 cells.

Keywords: Cytotoxicity; Depsidone; Dimeric xanthone; Garcinia esculenta; Prenylated xanthone.

MeSH terms

  • Antineoplastic Agents*
  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / pharmacology
  • Depsides*
  • Garcinia* / chemistry
  • Humans
  • Lactones*
  • Lung Neoplasms* / drug therapy
  • Molecular Structure
  • Xanthones* / chemistry
  • Xanthones* / pharmacology

Substances

  • depsidone
  • Antineoplastic Agents, Phytogenic
  • Antineoplastic Agents
  • Xanthones
  • Lactones
  • Depsides