Synthesis of iron-boride/carbon-nitride composites and their applications in chemodynamic therapy

Xiaoran Xu; Haixu Zhao; JiaJia Wang; Artem Kuklin; Hans Ågren; Xuefan Deng; Tianhe Huang; Glib Baryshnikov; Yongchang Wei; Haibo Zhang

doi:10.1016/j.jcis.2023.12.078

Synthesis of iron-boride/carbon-nitride composites and their applications in chemodynamic therapy

J Colloid Interface Sci. 2024 Mar 15:658:276-285. doi: 10.1016/j.jcis.2023.12.078. Epub 2023 Dec 14.

Authors

Xiaoran Xu¹, Haixu Zhao², JiaJia Wang², Artem Kuklin³, Hans Ågren³, Xuefan Deng⁴, Tianhe Huang⁵, Glib Baryshnikov⁶, Yongchang Wei⁷, Haibo Zhang⁸

Affiliations

¹ Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Cancer Clinical Study Center & Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan 430072, China.
² College of Chemistry and Molecular Sciences and National Demonstration Center for Experimental Chemistry, Wuhan University Wuhan, 430072, China.
³ Department of Physics and Astronomy, Division of X-ray Photon Science, Uppsala University. Lägerhyddsvägen 1, SE-75121 Uppsala, Sweden.
⁴ College of Chemistry and Molecular Sciences and National Demonstration Center for Experimental Chemistry, Wuhan University Wuhan, 430072, China. Electronic address: dxf_1221@whu.edu.cn.
⁵ Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Cancer Clinical Study Center & Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan 430072, China. Electronic address: zn004593@whu.edu.cn.
⁶ Department of Science and Technology, Linköping University, Norrköping 60174, Sweden. Electronic address: glib.baryshnikov@liu.se.
⁷ Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Cancer Clinical Study Center & Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan 430072, China. Electronic address: weiyongchang@whu.edu.cn.
⁸ College of Chemistry and Molecular Sciences and National Demonstration Center for Experimental Chemistry, Wuhan University Wuhan, 430072, China. Electronic address: haibozhang@whu.edu.cn.

PMID: 38104410
DOI: 10.1016/j.jcis.2023.12.078

Abstract

Chemodynamic therapy (CDT) is an emerging treatment strategy that inhibits tumor growth by catalyzing the generation of reactive oxygen species (ROS), such as hydroxyl radicals (•OH), using specific nanomaterials. Herein, we have developed a new class of iron-based nanomaterials, i.e., iron-based borides (FeB), using the superchaotropic effect of a boron cluster (closo-[B₁₂H₁₂]^2-) and organic ligands, followed by high-temperature calcination. Experimental data and theoretical calculations revealed that FeB nanoparticles exhibit a Fenton-like effect, efficiently decomposing hydrogen peroxide into •OH and thus increasing the concentration of ROS. FeB nanomaterials demonstrate excellent catalytic performance, efficiently generate ROS, and exert significant antitumor effects in cell experiments and animal models. Therefore, FeB nanomaterials have considerable potential for application in tumor treatment and offer new insights for the development of novel and efficient cancer therapy strategies.

Keywords: Boron cluster; CDT; Iron-based borides; Melanoma.

MeSH terms

Animals
Carbon
Catalysis
Cell Line, Tumor
Hydrogen Peroxide
Iron
Nanoparticles*
Neoplasms* / drug therapy
Reactive Oxygen Species

Substances

Reactive Oxygen Species
Hydrogen Peroxide
Iron
Carbon