Impact of protein coronas on nanoparticle interactions with tissues and targeted delivery

Wei-Chun Chou; Zhoumeng Lin

doi:10.1016/j.copbio.2023.103046

Impact of protein coronas on nanoparticle interactions with tissues and targeted delivery

Curr Opin Biotechnol. 2024 Feb:85:103046. doi: 10.1016/j.copbio.2023.103046. Epub 2023 Dec 16.

Authors

Wei-Chun Chou¹, Zhoumeng Lin²

Affiliations

¹ Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA; Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL 32608, USA.
² Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA; Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL 32608, USA. Electronic address: linzhoumeng@ufl.edu.

PMID: 38103519
PMCID: PMC11000521 (available on 2025-02-01)
DOI: 10.1016/j.copbio.2023.103046

Abstract

A major challenge in advancing nanoparticle (NP)-based delivery systems stems from the intricate interactions between NPs and biological systems. These interactions are largely determined by the formation of the NP-protein corona (PC), in which proteins spontaneously adsorb to the surface of NPs. The PC endows the NPs with a new biological identity, capable of altering the interactions of NPs with targeting organs and subsequent biological fate. This review discusses the mechanisms behind PC-mediated effects on tissue distribution of NPs, aiming to provide insights into the role of PC and its potential applications in NP-based drug delivery.

Publication types

Review

MeSH terms

Drug Delivery Systems
Nanoparticles*
Protein Corona* / metabolism
Proteins / metabolism
Tissue Distribution

Substances

Protein Corona
Proteins

Grants and funding

R01 EB031022/EB/NIBIB NIH HHS/United States