Stem Cell Therapy in Neonatal Hypoxic-Ischemic Encephalopathy and Cerebral Palsy: a Bibliometric Analysis and New Strategy

Qiu-Xia Xiao; Min-Jian Geng; Yi-Fei Sun; Yu Pi; Liu-Lin Xiong

doi:10.1007/s12035-023-03848-0

Stem Cell Therapy in Neonatal Hypoxic-Ischemic Encephalopathy and Cerebral Palsy: a Bibliometric Analysis and New Strategy

Mol Neurobiol. 2023 Dec 16. doi: 10.1007/s12035-023-03848-0. Online ahead of print.

Authors

Qiu-Xia Xiao^#¹, Min-Jian Geng^#², Yi-Fei Sun³, Yu Pi⁴, Liu-Lin Xiong⁵

Affiliations

¹ Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China.
² Department of Anesthesiology, Nanchong Central Hospital, Nanchong, 637000, Sichuan, China.
³ Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
⁴ Department of Anesthesiology, Southwest Medical University, Luzhou, 646000, Sichuan, China.
⁵ Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China. 499465010@qq.com.

^# Contributed equally.

PMID: 38102517
DOI: 10.1007/s12035-023-03848-0

Abstract

The aim of this study was to identify related scientific outputs and emerging topics of stem cells in neonatal hypoxic-ischemic encephalopathy (NHIE) and cerebral palsy (CP) through bibliometrics and literature review. All relevant publications on stem cell therapy for NHIE and CP were screened from websites and analyzed research trends. VOSviewer and CiteSpace were applied to visualize and quantitatively analyze the published literature to provide objective presentation and prediction. In addition, the clinical trials, published articles, and projects of the National Natural Science Foundation of China associated with stem cell therapy for NHIE and CP were summarized. A total of 294 publications were associated with stem cell therapy for NHIE and CP. Most publications and citations came from the USA and China. Monash University and University Medical Center Utrecht produced the most publications. Pediatric research published the most studies on stem cell therapy for NHIE and CP. Heijnen C and Kavelaars A published the most articles. Cluster analyses show that current research trend is more inclined toward the repair mechanism and clinical translation of stem cell therapy for NHIE and CP. By summarizing various studies of stem cells in NHIE and CP, it is indicated that this research direction is a hot topic at present. Furthermore, organoid transplantation, as an emerging and new therapeutic approach, brings new hope for the treatment of NHIE and CP. This study comprehensively summarized and analyzed the research trend of global stem cell therapy for NHIE and CP. It has shown a marked increase in stem cell therapy for NHIE and CP research. In the future, more efforts will be made on exploring stem cell or organoid therapy for NHIE and CP and more valuable related mechanisms of action to achieve clinical translation as soon as possible.

Keywords: Bibliometrics; Cerebral palsy; Neonatal hypoxic-ischemic encephalopathy; Organoid; Stem cells.

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Review

Abstract

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