Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses

Katheryn A G Begg; Hanna Braun; Nagham Ghaddar; Lillian Wu; Jessica A Downs

doi:10.1016/j.dnarep.2023.103609

Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses

DNA Repair (Amst). 2024 Jan:133:103609. doi: 10.1016/j.dnarep.2023.103609. Epub 2023 Nov 28.

Authors

Katheryn A G Begg¹, Hanna Braun¹, Nagham Ghaddar¹, Lillian Wu¹, Jessica A Downs²

Affiliations

¹ Division of Cancer Biology, The Institute of Cancer Research, London, UK.
² Division of Cancer Biology, The Institute of Cancer Research, London, UK. Electronic address: Jessica.Downs@icr.ac.uk.

PMID: 38101147
DOI: 10.1016/j.dnarep.2023.103609

Abstract

The mammalian SWI/SNF chromatin remodelling complexes are commonly dysregulated in cancer. These complexes contribute to maintaining genome stability through a variety of pathways. Recent research has highlighted an important interplay between genome instability and immune signalling, and evidence suggests that this interplay can modulate the response to immunotherapy. Here, we review emerging studies where direct evidence of this relationship has been uncovered in SWI/SNF deficient cells. We also highlight genome maintenance activities of SWI/SNF that could potentially shape immune responses and discuss potential therapeutic implications.

Keywords: ARID1A; BAF; CGAS/STING; Cancer; Chromatin remodelling; DNA damage; DNA repair; Double-strand break repair; Immunotherapy; Neoantigen; PBAF; PBRM1; SMARCA4; SWI/SNF.

Publication types

Review

MeSH terms

Animals
Chromatin Assembly and Disassembly
DNA Repair
Genomic Instability
Humans
Immunity
Mammals / genetics
Neoplasms* / genetics
Neoplasms* / metabolism
Nuclear Proteins / metabolism
Transcription Factors* / genetics
Transcription Factors* / metabolism

Substances

Transcription Factors
Nuclear Proteins