Activity-dependent constraints on catecholamine signaling

Li Li; Akshay N Rana; Esther M Li; Jiesi Feng; Yulong Li; Michael R Bruchas

doi:10.1016/j.celrep.2023.113566

Activity-dependent constraints on catecholamine signaling

Cell Rep. 2023 Dec 26;42(12):113566. doi: 10.1016/j.celrep.2023.113566. Epub 2023 Dec 14.

Authors

Li Li¹, Akshay N Rana², Esther M Li³, Jiesi Feng⁴, Yulong Li⁵, Michael R Bruchas⁶

Affiliations

¹ Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA; Seattle Children's Research Institute, Seattle, WA 98101, USA. Electronic address: lili1@uw.edu.
² Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA.
³ Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA; Department of Psychology, University of Washington, Seattle, WA 98105, USA.
⁴ State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
⁵ State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, New Cornerstone Science Laboratory, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
⁶ Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA. Electronic address: mbruchas@uw.edu.

PMID: 38100349
DOI: 10.1016/j.celrep.2023.113566

Abstract

Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and conditions. High tonic activity in vivo depleted catecholamine stores, desensitized postsynaptic responses, and decreased phasic transmission. Together, these findings provide a more complete understanding of the inverted-U relationship, offering insights into psychiatric disorders and neurodegenerative diseases with impaired catecholamine signaling.

Keywords: CP: Neuroscience; catecholamine; dopamine; locus coeruleus; neurotransmission; norepinephrine; phasic firing; tonic firing; ventral tegmental area.

MeSH terms

Catecholamines*
Dopamine
Humans
Locus Coeruleus* / physiology
Norepinephrine
Signal Transduction

Substances

Catecholamines
Norepinephrine
Dopamine