PDIA6, which is regulated by TRPM2-AS/miR-424-5p axis, promotes endometrial cancer progression via TGF-beta pathway

Cell Death Dis. 2023 Dec 14;14(12):829. doi: 10.1038/s41419-023-06297-8.

Abstract

PDIA6 have been reported to be involved in a variety of cancers, however, the underlying role in endometrial cancer is still unclear. In this study, we aimed to study the function of PDIA6 in endometrial cancer. Firstly, we verified that PDIA6 was significantly upregulated in endometrial cancer, which was correlated with the progression of endometrial cancer patients. Furthermore, we identified PDIA6 significantly altered the ability of endometrial cancer cells to proliferate and metastasize. In addition, our result illustrated the oncogene effects of PDIA6 in promoting malignant biological behavior of endometrial cancer cells by regulating TGF-β pathway and being modulated by TRPM2-AS/miR-424-5p axis for the first time. Taken together, this study suggested that PDIA6 may be a new candidate target for endometrial cancer therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Proliferation / genetics
  • Endometrial Neoplasms* / pathology
  • Female
  • Humans
  • MicroRNAs* / metabolism
  • Protein Disulfide-Isomerases / metabolism
  • TRPM Cation Channels* / genetics
  • Transforming Growth Factor beta / metabolism

Substances

  • MicroRNAs
  • TRPM Cation Channels
  • Transforming Growth Factor beta
  • TRPM2 protein, human
  • PDIA6 protein, human
  • Protein Disulfide-Isomerases
  • MIRN424 microrna, human