Vivax malaria and Duffy antigen: Stop being so negative

Patrick E Duffy; Karthigayan Gunalan; Louis H Miller

doi:10.1016/j.chom.2023.11.017

Vivax malaria and Duffy antigen: Stop being so negative

Cell Host Microbe. 2023 Dec 13;31(12):1959-1960. doi: 10.1016/j.chom.2023.11.017.

Authors

Patrick E Duffy¹, Karthigayan Gunalan², Louis H Miller²

Affiliations

¹ Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. Electronic address: patrick.duffy@nih.gov.
² Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD, USA.

PMID: 38096790
DOI: 10.1016/j.chom.2023.11.017

Abstract

Duffy blood group antigen (Duffy antigen/receptor for chemokines, atypical chemokine receptor-1, Duffy antigen), an essential Plasmodium vivax invasion receptor, is absent in most Africans. In this issue, two papers show erythroid precursors from Duffy-negative individuals transiently surface-express Duffy antigen and support vivax infection, potentially explaining low-density vivax infections across Africa.

Published by Elsevier Inc.

MeSH terms

Duffy Blood-Group System / genetics
Erythrocytes
Humans
Malaria, Vivax*
Plasmodium vivax
Protozoan Proteins / genetics

Substances

Duffy Blood-Group System
Protozoan Proteins