mSphere of Influence: How host genetics impact microbial pathogenesis and treatment of infectious disease

Emily E Rosowski

doi:10.1128/msphere.00629-23

mSphere of Influence: How host genetics impact microbial pathogenesis and treatment of infectious disease

mSphere. 2024 Jan 30;9(1):e0062923. doi: 10.1128/msphere.00629-23. Epub 2023 Dec 14.

Author

Emily E Rosowski^{1

2}

Affiliations

¹ Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA.
² Eukaryotic Pathogens Innovation Center, Clemson University, Clemson, South Carolina, USA.

Abstract

Emily Rosowski works in the field of host-pathogen interactions, studying how host innate immune mechanisms control pathogens. In this mSphere of Influence article, she reflects on how "Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections" by D. M. Tobin, F. J. Roca, S. F. Oh, R. McFarland, et al. (Cell 148:434-446, 2012, https://doi.org/10.1016/j.cell.2011.12.023) made an impact on her by investigating how differences in host genetics can affect modes of microbial pathogenesis and inform treatments for infectious disease.

Keywords: Aspergillus; Mycobacterium; host-pathogen interactions; zebrafish.

MeSH terms

Communicable Diseases* / therapy
Host-Pathogen Interactions*
Humans