Massive Left Ventricular Hypertrophy With Acromegaly: Hypertrophic Obstructive Cardiomyopathy Phenocopy or Phenotype?

Blair Tilkens; Patrycja Galazka; Joaquin Solis; John D Crouch; A Jamil Tajik

doi:10.1016/j.jaccas.2023.102033

Massive Left Ventricular Hypertrophy With Acromegaly: Hypertrophic Obstructive Cardiomyopathy Phenocopy or Phenotype?

JACC Case Rep. 2023 Sep 26:25:102033. doi: 10.1016/j.jaccas.2023.102033. eCollection 2023 Nov 1.

Authors

Blair Tilkens¹, Patrycja Galazka¹, Joaquin Solis¹, John D Crouch², A Jamil Tajik¹

Affiliations

¹ Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's Medical Centers, Milwaukee, Wisconsin, USA.
² Department of Cardiothoracic Surgery, Aurora Sinai/Aurora St. Luke's Medical Centers, Milwaukee, Wisconsin, USA.

Abstract

Acromegaly-a rare endocrine disorder-results when a growth hormone-secreting somatotroph pituitary adenoma leads to increased insulin-like growth factor 1 production. Acromegaly is known to cause left ventricular hypertrophy. We present a case of acromegaly with massive left ventricular hypertrophy that was determined to be coexistent with gene-positive hypertrophic obstructive cardiomyopathy. (Level of Difficulty: Intermediate.).

Keywords: cardiomyopathy; genetic disorders; mitral valve.