Sex-biased gut dopamine signaling in multiple sclerosis

Shui Yu; Melody Y Zeng

doi:10.1016/j.immuni.2023.11.016

Sex-biased gut dopamine signaling in multiple sclerosis

Immunity. 2023 Dec 12;56(12):2674-2676. doi: 10.1016/j.immuni.2023.11.016.

Authors

Shui Yu¹, Melody Y Zeng²

Affiliations

¹ Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY 10065, USA; Department of Pediatrics, Weill Cornell Medicine, New York, NY 10065, USA.
² Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY 10065, USA; Department of Pediatrics, Weill Cornell Medicine, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School, New York, NY 10065, USA. Electronic address: myz4001@med.cornell.edu.

Abstract

Multiple sclerosis shows a strong sex bias, with unclear mechanisms. In this issue of Immunity, Peng et al. elucidate a female-biased increase in intestinal dopamine signaling that diminishes protective Lactobacillus and exacerbates inflammation in a mouse model of multiple sclerosis.

MeSH terms

Animals
Dopamine
Female
Inflammation
Mice
Multiple Sclerosis*
Sexism

Substances

Dopamine

Abstract

MeSH terms

Substances

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