Common-path optical coherence tomography guided vertical pneumodissection for DALK

Yaning Wang; Shoujing Guo; Justin D Opfermann; James Kaluna; Bill G Gensheimer; Axel Krieger; Jin U Kang

doi:10.1117/12.2650533

Common-path optical coherence tomography guided vertical pneumodissection for DALK

Proc SPIE Int Soc Opt Eng. 2023 Feb:12372:1237204. doi: 10.1117/12.2650533. Epub 2023 Mar 6.

Authors

Yaning Wang¹, Shoujing Guo¹, Justin D Opfermann², James Kaluna², Bill G Gensheimer³, Axel Krieger², Jin U Kang¹

Affiliations

¹ Electrical and Computer Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
² Mechanical Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
³ Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, New Hampshire 03756, USA.

Abstract

We reported a design and evaluation of an optical coherence tomography (OCT) sensor-integrated 27 gauge vertically inserted razor edge cannula (VIREC) for pneumatic dissection of Descemet's membrane (DM) from the stromal layer. The VIREC was inserted vertically at the apex of the cornea to the desired depth near DM. The study was performed using ex vivo bovine corneas (N = 5) and rabbit corneas (N = 5). A clean penumodissection of a stromal layer was successfully performed using VIREC without any stomal blanching on bovine eyes. The "big bubble" was generated in all five tests without perforation. Only micro bubbles were observed on rabbit eyes. The results proved that VIREC can be an effective surgical option for "big bubble" DALK.

Keywords: DALK; Optical coherence tomography; optical distal sensor.

Grants and funding

R01 EY032127/EY/NEI NIH HHS/United States