Regulatory mechanism of macrophage polarization based on Hippo pathway

Yuanqing Liu; Yina An; Gebin Li; Shuaiyu Wang

doi:10.3389/fimmu.2023.1279591

Regulatory mechanism of macrophage polarization based on Hippo pathway

Front Immunol. 2023 Nov 28:14:1279591. doi: 10.3389/fimmu.2023.1279591. eCollection 2023.

Authors

Yuanqing Liu¹, Yina An¹, Gebin Li¹, Shuaiyu Wang^{1

2}

Affiliations

¹ The Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, China.
² Center of Research and Innovation of Chinese Traditional Veterinary Medicine, China Agricultural University, Beijing, China.

Abstract

Macrophages are found to infiltrate and migrate in a large number of Tumor-associated macrophages (TMEs) and other macrophages in the microenvironment of tumors and related diseases, and undergo phenotypic changes in response to a variety of cytokines, mainly including the primary phenotype M2 and the anti-tumor phenotype M1. The Hippo signaling pathway affects the development of cancer and other diseases through various biological processes, such as inhibition of cell growth. In this review, we focus on immune cells within the microenvironment of tumors and other diseases, and the role of the Hippo pathway in tumors on macrophage polarization in the tumor microenvironment (TME) and other diseases.

Keywords: Hippo; macrophages; polarization; regulation; tumor microenvironment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cytokines / metabolism
Hippo Signaling Pathway*
Humans
Macrophages
Neoplasms*
Phenotype
Tumor Microenvironment

Substances

Cytokines

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was funded by the National Natural Science Foundation Of China No.32172899.