Host cellular factors involved in pseudorabies virus attachment and entry: a mini review

Lei Tan; Kaixin Wang; Ping Bai; Shuo Zhang; Mengting Zuo; Xianghua Shu; Aibing Wang; Jun Yao

doi:10.3389/fvets.2023.1314624

Host cellular factors involved in pseudorabies virus attachment and entry: a mini review

Front Vet Sci. 2023 Nov 27:10:1314624. doi: 10.3389/fvets.2023.1314624. eCollection 2023.

Authors

Lei Tan^{1

2}, Kaixin Wang², Ping Bai³, Shuo Zhang³, Mengting Zuo⁴, Xianghua Shu⁵, Aibing Wang², Jun Yao⁶

Affiliations

¹ College of Animal Science, Yangtze University, Jingzhou, China.
² College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
³ Yunnan Southwest Agriculture and Animal Husbandry Group Co., Ltd, Kunming, China.
⁴ Hunan Provincial Key Laboratory of the TCM Agricultural Biogenomics, Changsha Medical University, Changsha, Hunan, China.
⁵ College of Animal Medicine, Yunnan Agricultural University, Kunming, China.
⁶ Yunnan Tropical and Subtropical Animal Virus Diseases Laboratory, Yunnan Animal Science and Veterinary Institute, Kunming, China.

Abstract

Pseudorabies virus (PRV) belongs to the Alphaherpesvirinae subfamily and serves as an exceptional animal model for investigating the infection mechanism of Herpes simplex virus type 1. Notably, PRV has the capability to infect a wide range of mammals, including humans, highlighting its potential as an overlooked zoonotic pathogen. The attachment and entry steps of PRV into host cells are crucial to accomplish its life cycle, which involve numerous cellular factors. In this mini review, we offer a comprehensive summary of current researches pertaining to the role of cellular factors in PRV attachment and entry stages, with the overarching goal of advancing the development of novel antiviral agents against this pathogen.

Keywords: antiviral strategies; cellular factors; involvement; pseudorabies virus; viral attachment and entry.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by the Major Specialized Projects of Yunnan Science and Technology (no. 202102AE090007) and Innovation Guidance and Technology-Based Enterprise Cultivation Program (no. 202304BI090003). Support was also provided by “Furong” Scholar funding to AW. Research and industrialization of large-scale and healthy pig farming technology (No. 202102AE090046).