A holistic approach to understanding immune-mediated inflammatory diseases: bioinformatic tools to integrate omics data

Gonzalo Borrego-Yaniz; Laura C Terrón-Camero; Martin Kerick; Eduardo Andrés-León; Javier Martin

doi:10.1016/j.csbj.2023.11.045

A holistic approach to understanding immune-mediated inflammatory diseases: bioinformatic tools to integrate omics data

Comput Struct Biotechnol J. 2023 Nov 28:23:96-105. doi: 10.1016/j.csbj.2023.11.045. eCollection 2024 Dec.

Authors

Gonzalo Borrego-Yaniz¹, Laura C Terrón-Camero², Martin Kerick¹, Eduardo Andrés-León², Javier Martin¹

Affiliations

¹ Genetic Basis of Autoimmune Diseases Group, Institute of Parasitology and Biomedicine López-Neyra (IPBLN), CSIC, Granada, Spain.
² Bioinformatics Unit, Institute of Parasitology and Biomedicine López-Neyra (IPBLN), CSIC, Granada, Spain.

Abstract

Immune-mediated inflammatory diseases (IMIDs) comprise a complex group of pathologies with diverse etiologies and clinical manifestations. In particular, omics technologies have remodeled our understanding of a set of IMIDs such as systemic autoimmune rheumatic diseases (SARDs), generating vast amounts of data on the genome, epigenome, transcriptome, proteome and metabolome of immune cells and SARDs patients. However, the integration of omics data to advance our knowledge of these diseases is challenging, requiring advanced bioinformatic tools. This review explores different multi-omic integrative tools for refining previous research, exploring the biological relevance of datasets within different contexts, or translating omics results into clinical advances. We also discuss relevant multi-omic studies in SARDs research and the potential of omics data from available repositories to complement ongoing investigation in this field.

Keywords: Bioinformatics; Immune-mediated inflammatory diseases; Integration; Omics.

Publication types

Review