Three new cadinene-type sesquiterpenoids from the aerial parts of Ageratina adenophora

Jia-Hui Luo; Wen-Jie Gu; En-Bo Zhang; Yi Huang; Yan-Hua Zhang; Yong-Xun Yang; Hao Geng

doi:10.1080/14786419.2023.2291820

Three new cadinene-type sesquiterpenoids from the aerial parts of Ageratina adenophora

Nat Prod Res. 2023 Dec 13:1-5. doi: 10.1080/14786419.2023.2291820. Online ahead of print.

Authors

Jia-Hui Luo¹, Wen-Jie Gu¹, En-Bo Zhang¹, Yi Huang¹, Yan-Hua Zhang¹, Yong-Xun Yang², Hao Geng¹

Affiliations

¹ School of Sciences, Xichang University, Xichang, Sichuan, P. R. China.
² School of Animal Sciences, Xichang University, Xichang, Sichuan, P. R. China.

PMID: 38087981
DOI: 10.1080/14786419.2023.2291820

Abstract

Three new cadinene sesquiterpenoids 1-3, were isolated from the aerial sections of Ageratina adenophora using various chromatographic techniques. Their structures were characterised by comprehensive spectroscopic investigations (including 1D, 2D-NMR and HRMS), and single crystal X-ray diffraction. The cytotoxic activity of new compounds 1-3 were evaluated by testing in vitro tumour growth inhibitory rate against five human tumour cell lines, HL-60, A-549, SMMC-7721, MDA-MB-231, and SW480.

Keywords: Asteraceae; ageratina adenophora; cadinene-type sesquiterpenoids; chemical structures.