Effect of Lavandula angustifolia and Cananga odorata on decrease of blood pressure in high blood pressure volunteers: A randomized controlled trial

Supamas Napavichayanun; Alisara Sangviroon Sujarit; Prompong Pienpinijtham; Ariya Sarikaphuti; Pornanong Aramwit

doi:10.1016/j.explore.2023.11.013

Effect of Lavandula angustifolia and Cananga odorata on decrease of blood pressure in high blood pressure volunteers: A randomized controlled trial

Explore (NY). 2023 Nov 29:S1550-8307(23)00271-9. doi: 10.1016/j.explore.2023.11.013. Online ahead of print.

Authors

Supamas Napavichayanun¹, Alisara Sangviroon Sujarit², Prompong Pienpinijtham³, Ariya Sarikaphuti⁴, Pornanong Aramwit⁵

Affiliations

¹ Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Center of Excellence in Bioactive Resources for Innovative Clinical Applications, Chulalongkorn University, Bangkok, Thailand.
² Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
³ Center of Excellence in Bioactive Resources for Innovative Clinical Applications, Chulalongkorn University, Bangkok, Thailand; Sensor Research Unit (SRU), Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand; National Nanotechnology Center of Advanced Structural and Functional Nanomaterials, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
⁴ School of Anti-Aging and Regenerative Medicine, Mae FahLuang University, Bangkok, Thailand.
⁵ Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Center of Excellence in Bioactive Resources for Innovative Clinical Applications, Chulalongkorn University, Bangkok, Thailand. Electronic address: Pornanong.A@chula.ac.th.

PMID: 38087747
DOI: 10.1016/j.explore.2023.11.013

Abstract

Introduction: Hypertension is one of the most dangerous diseases. However, medicine for hypertension may cause adverse effects. Thus, alternative treatments may be beneficial to patients. The aims of the study were to evaluate efficacy and safety of sticker pads containing lavender and ylang ylang oil (LY pads) on decrease blood pressure.

Materials and methods: The LY pads had been developed since 2018. The safety of LY pads in healthy volunteers' study and the efficacy and safety of LY pads in high blood pressure volunteers' study were conducted at Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand in October 2020 to December 2022. In the safety of LY pads in healthy volunteers' study, the LY pad was attached to the shirts of 56 healthy volunteers for 2 h. Adverse reactions, irritation score, and quality of life were assessed. In the efficacy and safety of the LY pads in high blood pressure volunteers' study, 34 high blood pressure volunteers were randomly divided into the LY group or the placebo group. The volunteers attached the pad to their shirt for 14 days. Blood pressure, pulse rate, and adverse reactions were investigated.

Results: The LY pad was safe for humans. Using the LY pad for 2 h had no significant adverse reactions in healthy volunteers. Moreover, it significantly improved quality of life (p<0.05). The blood pressure of the LY pad group after at least 3 days use was significantly lower than before using the pad (p<0.05). The systolic blood pressure difference and pulse rate difference were also superior in the LY pad group compared to the placebo group (p<0.05).

Conclusions: The LY pad was safe in healthy volunteers and could reduce blood pressure in high blood pressure volunteers without adverse effects. Thus, it may be a supportive or alternative treatment for hypertension.

Keywords: Blood pressure; Cananga; Hypertension; Lavandula; Oils; Volatile.