Pleomorphic adenoma with extensive squamous and mucinous metaplasia and a novel MALAT1::PLAG1 fusion gene

Cytopathology. 2024 Mar;35(2):283-285. doi: 10.1111/cyt.13347. Epub 2023 Dec 12.

Abstract

Cases of metaplastic pleomorphic adenoma can be diagnostically challenging. Many of these cases fall into the Milan system's SUMP category, and some may be misdiagnosed. The author shows a case of pleomorphic adenoma with extensive squamous and mucinous metaplasia and a novel MALAT1::PLAG1 fusion.

Publication types

  • Case Reports

MeSH terms

  • Adenoma, Pleomorphic* / diagnosis
  • Adenoma, Pleomorphic* / genetics
  • Carcinoma, Squamous Cell*
  • DNA-Binding Proteins / genetics
  • Humans
  • Metaplasia / diagnosis
  • Metaplasia / genetics
  • RNA, Long Noncoding* / genetics
  • Salivary Gland Neoplasms*
  • Transcription Factors / genetics

Substances

  • DNA-Binding Proteins
  • PLAG1 protein, human
  • RNA, Long Noncoding
  • Transcription Factors
  • MALAT1 long non-coding RNA, human