Background: Glycolipid metabolism disorders (dysglycolipidemia) are characterized by elevated levels of glycolipid profile components and fasting blood glucose. Dysglycolipidemia are major threats to human health and life. Therefore, the aim of this cross-sectional study is to estimate the prevalence of dysglycolipidemia and the existence of association of TSH and T4 and glycolipid profiles.
Methods: Cross-sectional data were obtained from the medical laboratory of Ma'an Governmental Hospital. A total of 141 patients' results were collected (18-60 years). Differences in the glycolipidemic profiles according to age and sex and TSH and T4 were compared. Different statistical analyses were used to analyze the prevalence of dysglycolipidemia and the correlation with the levels of TSH and T4.
Results: The study involved results of 141 patients (54.7% males and 45.3% females) in Ma'an Province (Jordan), who visited the internal medicine clinic at Ma'an Governmental Hospital. Patients have overweight and BMI of more than 25 kg/m2. The overall results of the prevalence of dyslipidemia indicated that patients have 42.5% of hypercholesterolemia, 48.2% of high LDL-C, 34.1% of hypertriglyceridemia, and 41.8% of low HDL-C. The prevalence of isolated lipid profiles showed that 10 patients have mixed dyslipidemia. The association of dyslipidemia with age indicated a positive significance between triglyceride and older people (≥40 years), while HDL levels have a significance with gender (p=0.025). The overall ANOVA model yielded non-statistical significant results between levels of any components of lipid profile and levels of TSH and T4 hormones. Welch test (p=0.036) showed positive significance between levels of fasting blood glucose and triglyceride levels.
Conclusions: Our results showed and confirmed the presence of a high percentage of hyperlipidemia in Ma'an province and there was no relationship with levels of TSH and T4. A relationship exists between levels of triglycerides and blood glucose concentrations.
Uvod: Poremećaji metabolizma glikolipida (disglikolipidemija) karakterišu povišeni nivoi komponenti glikolipidnog profila i glukoze u krvi natašte. Disglikolipidemija je glavna pretnja ljudskom zdravlju i životu. Stoga je cilj ove studije preseka da se proceni prevalencija disglikolipidemije i postojanje povezanosti TSH i T4 i glikolipidnih profila.
Metode: Podaci o poprečnom preseku su dobijeni iz medicinske laboratorije Vladine bolnice Ma'an. Prikupljeno je ukupno 141 rezultata pacijenata (18-60 godina). Upoređene su razlike u profilima glikolipidemije prema starosti i polu i TSH i T4. Različitim statističkim analizama analizirana je prevalencija disglikolipidemije i korelacija sa nivoima TSH i T4.
Rezultati: Studija je obuhvatila rezultate 141 pacijenta (54,7% muškaraca i 45,3% žena) u provinciji Ma'an (Jordan), koji su posetili kliniku interne medicine u Vladinoj bolnici Ma'an. Pacijenti imaju prekomernu težinu i BMI veći od 25 kg/m2. Ukupni rezultati prevalencije dislipidemije su pokazali da pacijenti imaju 42,5% hiperholesterolemije, 48,2% visokog LDL-C, 34,1% hipertrigliceridemije i 41,8% niskog HDL-C. Prevalencija izolovanih lipidnih profila pokazala je da 10 pacijenata ima mešovitu dislipidemiju. Povezanost dislipidemije sa uzrastom ukazala je na pozitivan značaj između triglicerida i starijih osoba (≥40 godina), dok nivoi HDL-a imaju značaj za pol (p=0,025). Ukupni ANOVA model je dao nestatistički značajne rezultate između nivoa bilo koje komponente lipidnog profila i nivoa TSH i T4 hormona. Velch test (p=0,036) pokazao je pozitivan značaj između nivoa glukoze u krvi natašte i nivoa triglicerida.
Zaključak: Naši rezultati su pokazali i potvrdili prisustvo visokog procenta hiperlipidemije u provinciji Ma'an i nije bilo veze sa nivoima TSH i T4. Postoji veza između nivoa triglicerida i koncentracije glukoze u krvi.
Keywords: T4; TSH; fasting blood glucose; high LDC; hypercholesterolemia; hypertriglyceridemia; low HDL.
2023 Omar Mohammad Atrooz, Mazen Nayef Hiresh, Alghonmeen Reham Dlewan, Mohammad Omar Atrooz, Ghofran Nayef Hiresh, Aseel Mahmoud Alasoufi, Ihssan Omar Atrooz, published by CEON/CEES.