Aging cells experience a gradual degeneration of their chemical and physical characteristics, resulting in the declining body functions that are commonly observed in old age. In this paper, we propose a novel microsystem that utilizes acoustics and electricity to investigate the effects of mechanical cyclic loading on cellular aging. Our study is the first to examine how mechanical loading influences the physicochemical characteristics of lipid bilayer at the subcellular level. By providing a new method for understanding the mechanism of cellular aging and aging-related diseases, our microsystem has significant implications for the development of treatments and therapies.Clinical Relevance- This ultrasonic-electric-based microsystem, as an in vitro model with sensitive quantitative capabilities, could have significant clinical implications in terms of understanding cellular responses to mechanical forces, elucidating the pathogenesis of aging-related diseases, and developing therapeutic strategies.