This study aimed to compare and proposed an analytical method for evaluating the effectiveness of massage using various measurement parameters. The parameters were divided psychologically using the Profile of Mood States (POMS) and physiologically using heart rate variability. In the experiment, the psycho-physiological effects of the rest(a) and two massage techniques (b, c) were evaluated. The effect of each massage technique on the parameters was examined, and a statistical analysis approach for evaluating massage responses is given in the conclusion.Clinical Relevance- This case study compares and contrasts the differences and advantages of each statistical approach for analyzing on studying the effects of massage and presents the response results for two massage techniques.