Is Protein BLAST a thing of the past?

Ali Al-Fatlawi; Martin Menzel; Michael Schroeder

doi:10.1038/s41467-023-44082-5

Is Protein BLAST a thing of the past?

Nat Commun. 2023 Dec 11;14(1):8195. doi: 10.1038/s41467-023-44082-5.

Authors

Ali Al-Fatlawi^{1

2}, Martin Menzel¹, Michael Schroeder^{3

4}

Affiliations

¹ Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany.
² Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI), Dresden, Germany.
³ Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany. michael.schroeder@tu-dresden.de.
⁴ Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI), Dresden, Germany. michael.schroeder@tu-dresden.de.

Abstract

Will protein structure search tools like AlphaFold replace protein sequence search with BLAST? We discuss the promises, using structure search for remote homology detection, and why protein BLAST, as the leading sequence search tool, should strive to incorporate structural information

MeSH terms

Databases, Protein*
Proteins* / genetics

Substances

Proteins